The effects of herbal cream and silymarin on liver in carbon tetrachloride-treated animals

Asli Kandil; Aysu Kılıc; Ebru Gürel Gürevin; İbrahim Söğüt; Savaş Üstünova; Şeyma Eren; Metin Caner; Cihan Demirci Tansel

Article Details

The effects of herbal cream and silymarin on liver in carbon tetrachloride-treated animals

Authors:

Asli Kandil | Aysu Kılıc | Ebru Gürel Gürevin | İbrahim Söğüt | Savaş Üstünova | Şeyma Eren | Metin Caner | Cihan Demirci Tansel

Publisher:

Ankara University

Main Topics:

Veterinary Anatomy and Physiology

Journal:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.72 Issue 1, pp.47-57

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001331600

pISSN:

1300-0861

Keywords:

Abstract:

 Many medical or pharmaceutical plants have been widely used for the treatment of the liver injury. Silymarin is now used as a food-supporting material for the liver as a patented product. Herbal cream has anti-inflammatory and antioxidant effects on wound healing in a hemorrhoid model. This study aimed to evaluate the effects of herbal cream and silymarin on the liver in carbon tetrachloride CCl4-treated animals. Male Wistar rats were divided into seven groups as Intact control, Control, Herbal cream 0.5 ml, intrarectal, Silymarin 70 mgkg, intrarectal, CCl4 2 mlkg, intraperitoneal, CCl4Herbal cream 0.5 ml herbal cream for 21 days, 3 weeks after administration of CCl₄ and CCl4Silymarin 70 mgkg silymarin for 21 days, 3 weeks after administration of CCl₄. Herbal cream reduced damage and leukocyte distribution induced by CCl4 and increased catalase. There was no significant change in superoxide dismutase SOD and glutathione peroxidase GPx. The levels of SOD, catalase, and GPx in the liver increased significantly in the group treated only with herbal cream. These results point out that herbal cream may have antioxidant properties in the liver and a role in preventing liver damage. As a result, it has been detected that herbal cream is not a toxic agent and recovers liver damage with antioxidant properties.

 Many medical or pharmaceutical plants have been widely used for the treatment of the liver injury. Silymarin is now used as a food-supporting material for the liver as a patented product. Herbal cream has anti-inflammatory and antioxidant effects on wound healing in a hemorrhoid model. This study aimed to evaluate the effects of herbal cream and silymarin on the liver in carbon tetrachloride CCl4-treated animals. Male Wistar rats were divided into seven groups as Intact control, Control, Herbal cream 0.5 ml, intrarectal, Silymarin 70 mgkg, intrarectal, CCl4 2 mlkg, intraperitoneal, CCl4Herbal cream 0.5 ml herbal cream for 21 days, 3 weeks after administration of CCl₄ and CCl4Silymarin 70 mgkg silymarin for 21 days, 3 weeks after administration of CCl₄. Herbal cream reduced damage and leukocyte distribution induced by CCl4 and increased catalase. There was no significant change in superoxide dismutase SOD and glutathione peroxidase GPx. The levels of SOD, catalase, and GPx in the liver increased significantly in the group treated only with herbal cream. These results point out that herbal cream may have antioxidant properties in the liver and a role in preventing liver damage. As a result, it has been detected that herbal cream is not a toxic agent and recovers liver damage with antioxidant properties.

 Many medical or pharmaceutical plants have been widely used for the treatment of the liver injury. Silymarin is now used as a food-supporting material for the liver as a patented product. Herbal cream has anti-inflammatory and antioxidant effects on wound healing in a hemorrhoid model. This study aimed to evaluate the effects of herbal cream and silymarin on the liver in carbon tetrachloride CCl4-treated animals. Male Wistar rats were divided into seven groups as Intact control, Control, Herbal cream 0.5 ml, intrarectal, Silymarin 70 mgkg, intrarectal, CCl4 2 mlkg, intraperitoneal, CCl4Herbal cream 0.5 ml herbal cream for 21 days, 3 weeks after administration of CCl₄ and CCl4Silymarin 70 mgkg silymarin for 21 days, 3 weeks after administration of CCl₄. Herbal cream reduced damage and leukocyte distribution induced by CCl4 and increased catalase. There was no significant change in superoxide dismutase SOD and glutathione peroxidase GPx. The levels of SOD, catalase, and GPx in the liver increased significantly in the group treated only with herbal cream. These results point out that herbal cream may have antioxidant properties in the liver and a role in preventing liver damage. As a result, it has been detected that herbal cream is not a toxic agent and recovers liver damage with antioxidant properties.

 Many medical or pharmaceutical plants have been widely used for the treatment of the liver injury. Silymarin is now used as a food-supporting material for the liver as a patented product. Herbal cream has anti-inflammatory and antioxidant effects on wound healing in a hemorrhoid model. This study aimed to evaluate the effects of herbal cream and silymarin on the liver in carbon tetrachloride CCl4-treated animals. Male Wistar rats were divided into seven groups as Intact control, Control, Herbal cream 0.5 ml, intrarectal, Silymarin 70 mgkg, intrarectal, CCl4 2 mlkg, intraperitoneal, CCl4Herbal cream 0.5 ml herbal cream for 21 days, 3 weeks after administration of CCl₄ and CCl4Silymarin 70 mgkg silymarin for 21 days, 3 weeks after administration of CCl₄. Herbal cream reduced damage and leukocyte distribution induced by CCl4 and increased catalase. There was no significant change in superoxide dismutase SOD and glutathione peroxidase GPx. The levels of SOD, catalase, and GPx in the liver increased significantly in the group treated only with herbal cream. These results point out that herbal cream may have antioxidant properties in the liver and a role in preventing liver damage. As a result, it has been detected that herbal cream is not a toxic agent and recovers liver damage with antioxidant properties.

Article Details

The effects of herbal cream and silymarin on liver in carbon tetrachloride-treated animals

Authors:

Asli Kandil | Aysu Kılıc | Ebru Gürel Gürevin | İbrahim Söğüt | Savaş Üstünova | Şeyma Eren | Metin Caner | Cihan Demirci Tansel

Publisher:

Ankara University

Main Topics:

Veterinary Anatomy and Physiology

Journal:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.72 Issue 1, pp.47-57

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001331600

pISSN:

1300-0861

Carbon tetrachloride

Herbal cream

Liver

Oxidative stress

Silymarin.

Issues

Article Details

The effects of herbal cream and silymarin on liver in carbon tetrachloride-treated animals

Authors: Asli Kandil | Aysu Kılıc | Ebru Gürel Gürevin | İbrahim Söğüt | Savaş Üstünova | Şeyma Eren | Metin Caner | Cihan Demirci Tansel

Publisher: Ankara University

Main Topics: Veterinary Anatomy and Physiology

Journal: Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.72 Issue 1, pp.47-57

Document Type: Article

Publication Date: 1/2025

Document Language: English

Document ID (Org No.): 2001331600

pISSN: 1300-0861

Carbon tetrachloride

Herbal cream

Liver

Oxidative stress

Silymarin.

Issues

Authors:

Asli Kandil | Aysu Kılıc | Ebru Gürel Gürevin | İbrahim Söğüt | Savaş Üstünova | Şeyma Eren | Metin Caner | Cihan Demirci Tansel

Publisher:

Ankara University

Main Topics:

Veterinary Anatomy and Physiology

Journal:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.72 Issue 1, pp.47-57

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001331600

pISSN:

1300-0861