The Effect of Serum and Follicle Fluid Melatonin Levels on In-Vitro Fertilization Success Between Polycystic Ovary Syndrome and Unexplained Infertility Patient Groups in In-Vitro Fertilization

Deniz Taşkıran; Özgür Koçak; Ercan Ayaz; Ümit Görkem; Cihan Toğrul

Article Details

The Effect of Serum and Follicle Fluid Melatonin Levels on In-Vitro Fertilization Success Between Polycystic Ovary Syndrome and Unexplained Infertility Patient Groups in In-Vitro Fertilization

Authors:

Deniz Taşkıran | Özgür Koçak | Ercan Ayaz | Ümit Görkem | Cihan Toğrul

Publisher:

Hitit University

Main Topics:

Kadın Hastalıkları ve Doğum

Journal:

Hitit Medical Journal Vol.7 Issue 1, pp.70-77

Document Type:

Article

Publication Date:

2/2025

Document Language:

Turkish

Document ID (Org No.):

2001341683

pISSN:

2687-4717

Keywords:

Abstract:

 Objective: To investigate the difference in the serum melatonin and follicle fluid melatonin levels at unexplained infertility and polycystic ovary syndrome PCOS patients who underwent in-vitro fertilization IVF treatment, and to investigate whether the melatonin level affects oocyte quality, embryo number, and clinical pregnancy. Material and Method: Women with unexplained infertility n26 and women with the polycystic ovarian syndrome n26 who started IVF treatment were included in this prospective trial. The levels of melatonin in the groups were tested using the enzyme-linked immunosorbent ELIZA method. In addition, the effect of the difference in melatonin levels between the groups on IVF success was investigated. Results: Patients with the polycystic ovarian syndrome had significantly low serum melatonin levels p0.018. Melatonin levels in follicular fluid were similar in both groups p0.701. Total oocyte, M2 oocyte, PN2 oocyte, grade A embryo, second-day embryo count, and the number of transferred embryos did not differ across the groups p0.05. There was no significant relationship between serum and follicular fluid melatonin levels p0.05. There was no significant relationship between clinical pregnancy and melatonin level p0.05. There was no statistical difference between the groups regarding age, weight, height, and body mass index p0.05. Conclusion: In our study, serum melatonin levels were lower in infertile women with polycystic ovary syndrome. This may be due to high melatonin consumption. However, melatonin levels in the serum and follicular fluid had no direct effect on IVF outcomes.

 Objective: To investigate the difference in the serum melatonin and follicle fluid melatonin levels at unexplained infertility and polycystic ovary syndrome PCOS patients who underwent in-vitro fertilization IVF treatment, and to investigate whether the melatonin level affects oocyte quality, embryo number, and clinical pregnancy. Material and Method: Women with unexplained infertility n26 and women with the polycystic ovarian syndrome n26 who started IVF treatment were included in this prospective trial. The levels of melatonin in the groups were tested using the enzyme-linked immunosorbent ELIZA method. In addition, the effect of the difference in melatonin levels between the groups on IVF success was investigated. Results: Patients with the polycystic ovarian syndrome had significantly low serum melatonin levels p0.018. Melatonin levels in follicular fluid were similar in both groups p0.701. Total oocyte, M2 oocyte, PN2 oocyte, grade A embryo, second-day embryo count, and the number of transferred embryos did not differ across the groups p0.05. There was no significant relationship between serum and follicular fluid melatonin levels p0.05. There was no significant relationship between clinical pregnancy and melatonin level p0.05. There was no statistical difference between the groups regarding age, weight, height, and body mass index p0.05. Conclusion: In our study, serum melatonin levels were lower in infertile women with polycystic ovary syndrome. This may be due to high melatonin consumption. However, melatonin levels in the serum and follicular fluid had no direct effect on IVF outcomes.

 Objective: To investigate the difference in the serum melatonin and follicle fluid melatonin levels at unexplained infertility and polycystic ovary syndrome PCOS patients who underwent in-vitro fertilization IVF treatment, and to investigate whether the melatonin level affects oocyte quality, embryo number, and clinical pregnancy. Material and Method: Women with unexplained infertility n26 and women with the polycystic ovarian syndrome n26 who started IVF treatment were included in this prospective trial. The levels of melatonin in the groups were tested using the enzyme-linked immunosorbent ELIZA method. In addition, the effect of the difference in melatonin levels between the groups on IVF success was investigated. Results: Patients with the polycystic ovarian syndrome had significantly low serum melatonin levels p0.018. Melatonin levels in follicular fluid were similar in both groups p0.701. Total oocyte, M2 oocyte, PN2 oocyte, grade A embryo, second-day embryo count, and the number of transferred embryos did not differ across the groups p0.05. There was no significant relationship between serum and follicular fluid melatonin levels p0.05. There was no significant relationship between clinical pregnancy and melatonin level p0.05. There was no statistical difference between the groups regarding age, weight, height, and body mass index p0.05. Conclusion: In our study, serum melatonin levels were lower in infertile women with polycystic ovary syndrome. This may be due to high melatonin consumption. However, melatonin levels in the serum and follicular fluid had no direct effect on IVF outcomes.

 Amaç: Açıklanamayan infertilite ve tüp bebek tedavisi gören PKOS Polikistik Over Sendromu hastalarında serum ve folikül sıvısı melatonin düzeyleri arasındaki farkı araştırmak ve melatonin düzeyinin oosit kalitesi, embriyo sayısı ve klinik gebelik üzerine etkilerini araştırmak. Gereç ve Yöntem: Bu prospektif çalışmaya, açıklanamayan infertilitesi olan kadınlar n26 ve polikistik over sendromlu n26 tüp bebek tedavisine başlayan kadınlar dahil edildi. Grupların serum ve foliküler sıvısındaki melatonin düzeyleri ELIZA yöntemi kullanılarak test edildi. Ayrıca gruplar arasındaki melatonin düzeyi farklılığının IVF başarısına etkisi araştırıldı. Bulgular: Polikistik over sendromlu hastaların serum melatonin düzeyleri anlamlı düzeyde az idi p0.018. Foliküler sıvıdaki melatonin düzeyleri her iki grupta da benzerdi p0.701. Toplam oosit, M2 oosit, PN2 oosit, A sınıfı embriyo, ikinci gün embriyo sayısı ve transfer edilen embriyo sayısı açısından gruplar arasında anlamlı fark yoktu p0.05. Serum ve foliküler sıvı melatonin düzeyleri arasında anlamlı bir ilişki saptanmadı p0.05. Klinik gebelik ile melatonin düzeyi arasında anlamlı bir ilişki bulunmadı p0.05. Gruplar arasında yaş, kilo, boy ve vücut kitle indeksi açısından istatistiksel fark yoktu p0.05. Sonuç: Çalışmamızda polikistik over sendromlu infertil kadınlarda serum melatonin düzeyleri daha düşüktü. Bunun nedeni yüksek melatonin tüketimi olabilir. Ancak serum ve foliküler sıvıdaki melatonin düzeylerinin IVF sonucuna doğrudan bir etkisinin olmadığı görüldü.

Article Details

The Effect of Serum and Follicle Fluid Melatonin Levels on In-Vitro Fertilization Success Between Polycystic Ovary Syndrome and Unexplained Infertility Patient Groups in In-Vitro Fertilization

Authors:

Deniz Taşkıran | Özgür Koçak | Ercan Ayaz | Ümit Görkem | Cihan Toğrul

Publisher:

Hitit University

Main Topics:

Kadın Hastalıkları ve Doğum

Journal:

Hitit Medical Journal Vol.7 Issue 1, pp.70-77

Document Type:

Article

Publication Date:

2/2025

Document Language:

Turkish

Document ID (Org No.):

2001341683

pISSN:

2687-4717

Unexplained infertility

Follicular Fluid

Melatonin

PCOSAçıklanamayan İnfertilite

Foliküler Sıvı

Melatonin

Polikistik Over Sendromu

Issues

Article Details

Authors: Deniz Taşkıran | Özgür Koçak | Ercan Ayaz | Ümit Görkem | Cihan Toğrul

Publisher: Hitit University

Main Topics: Kadın Hastalıkları ve Doğum

Journal: Hitit Medical Journal Vol.7 Issue 1, pp.70-77

Document Type: Article

Publication Date: 2/2025

Document Language: Turkish

Document ID (Org No.): 2001341683

pISSN: 2687-4717

Issues

Authors:

Deniz Taşkıran | Özgür Koçak | Ercan Ayaz | Ümit Görkem | Cihan Toğrul

Publisher:

Hitit University

Main Topics:

Kadın Hastalıkları ve Doğum

Journal:

Hitit Medical Journal Vol.7 Issue 1, pp.70-77

Document Type:

Article

Publication Date:

2/2025

Document Language:

Turkish

Document ID (Org No.):

2001341683

pISSN:

2687-4717