Evaluation of Henle Nerve Fiber Layer by Optical Coherence Tomography in Thyroid Eye Disease

Mehmet Fatih Kağan Değirmenci; Nazan Acar Eser

Article Details

Evaluation of Henle Nerve Fiber Layer by Optical Coherence Tomography in Thyroid Eye Disease

Authors:

Mehmet Fatih Kağan Değirmenci | Nazan Acar Eser

Publisher:

Zonguldak Bulent Ecevit University

Main Topics:

Cerrahi (Diğer)

Journal:

Batı Karadeniz Tıp Dergisi Vol.8 Issue 3, pp.341-347

Document Type:

Article

Publication Date:

12/2024

Document Language:

Turkish

Document ID (Org No.):

2001337522

pISSN:

2822-4302

Keywords:

Abstract:

 Aim: The aim of this study was to evaluate the Henles nerve fiber layer HNFL consisting of photoreceptors and Müller cells in individuals with Thyroid Eye Disease TED using optical coherence tomography OCT and to compare it with healthy individuals. Material and Methods: Twenty eyes of 20 patients with inactive mild TED Group-1 and 20 eyes of 20 age- and gender-matched healthy participants Group-2 were retrospectively included in the study. Detailed ocular examination findings of all participants were recorded. Retinal thickness obtained by OCT and central 500 and 1000 μm wide HNFL area, measured by ImageJ software, were recorded. The findings were statistically compared between the two groups. Results: There was no significant difference in mean age and gender distribution between the groups p0.05. Mean best corrected visual acuity, intraocular pressure, spherical equivalent, axial length and anterior chamber depth were similar between the two groups p0.05 for all. Retinal thickness and choroidal thickness were not significantly different between the two groups p0.05. The mean HNFL area in the central 500 μm region was significantly higher in group-1 than in group-2 Group-1: 25678,4  5372,0 μm2 vs. group-2: 23375,0  3974,5 μm2, p0.010. In the central 1000 μm region, the mean HSLT areas were similar between the two groups Group-1: 99859,9  9936,4 μm2 vs group-2: 97563,0  8478,4 μm2, p0.090. Conclusion: The findings of our study show an increased HNFL area consisting of photoreceptors and Müller cells in the central foveal region in eyes with mild and inactive TED. Evaluation of HNFL may be promising for early detection and follow-up of TED.

 Aim: The aim of this study was to evaluate the Henles nerve fiber layer HNFL consisting of photoreceptors and Müller cells in individuals with Thyroid Eye Disease TED using optical coherence tomography OCT and to compare it with healthy individuals. Material and Methods: Twenty eyes of 20 patients with inactive mild TED Group-1 and 20 eyes of 20 age- and gender-matched healthy participants Group-2 were retrospectively included in the study. Detailed ocular examination findings of all participants were recorded. Retinal thickness obtained by OCT and central 500 and 1000 μm wide HNFL area, measured by ImageJ software, were recorded. The findings were statistically compared between the two groups. Results: There was no significant difference in mean age and gender distribution between the groups p0.05. Mean best corrected visual acuity, intraocular pressure, spherical equivalent, axial length and anterior chamber depth were similar between the two groups p0.05 for all. Retinal thickness and choroidal thickness were not significantly different between the two groups p0.05. The mean HNFL area in the central 500 μm region was significantly higher in group-1 than in group-2 Group-1: 25678,4  5372,0 μm2 vs. group-2: 23375,0  3974,5 μm2, p0.010. In the central 1000 μm region, the mean HSLT areas were similar between the two groups Group-1: 99859,9  9936,4 μm2 vs group-2: 97563,0  8478,4 μm2, p0.090. Conclusion: The findings of our study show an increased HNFL area consisting of photoreceptors and Müller cells in the central foveal region in eyes with mild and inactive TED. Evaluation of HNFL may be promising for early detection and follow-up of TED.

 Aim: The aim of this study was to evaluate the Henles nerve fiber layer HNFL consisting of photoreceptors and Müller cells in individuals with Thyroid Eye Disease TED using optical coherence tomography OCT and to compare it with healthy individuals. Material and Methods: Twenty eyes of 20 patients with inactive mild TED Group-1 and 20 eyes of 20 age- and gender-matched healthy participants Group-2 were retrospectively included in the study. Detailed ocular examination findings of all participants were recorded. Retinal thickness obtained by OCT and central 500 and 1000 μm wide HNFL area, measured by ImageJ software, were recorded. The findings were statistically compared between the two groups. Results: There was no significant difference in mean age and gender distribution between the groups p0.05. Mean best corrected visual acuity, intraocular pressure, spherical equivalent, axial length and anterior chamber depth were similar between the two groups p0.05 for all. Retinal thickness and choroidal thickness were not significantly different between the two groups p0.05. The mean HNFL area in the central 500 μm region was significantly higher in group-1 than in group-2 Group-1: 25678,4  5372,0 μm2 vs. group-2: 23375,0  3974,5 μm2, p0.010. In the central 1000 μm region, the mean HSLT areas were similar between the two groups Group-1: 99859,9  9936,4 μm2 vs group-2: 97563,0  8478,4 μm2, p0.090. Conclusion: The findings of our study show an increased HNFL area consisting of photoreceptors and Müller cells in the central foveal region in eyes with mild and inactive TED. Evaluation of HNFL may be promising for early detection and follow-up of TED.

 Amaç: Tiroid Göz Hastalığı TGH olan bireylerde, fotoreseptör ve Müller hücrelerinden oluşan Henle sinir lifi tabakasının HSLT optik koherens tomografi OKT ile değerlendirilerek sağlıklı bireylerde kıyaslanması amaçlanmıştır. Gereç ve Yöntemler: İnaktif hafif seviyede TGH olan 20 hastanın 20 gözü Grup-1 ile yaş ve cinsiyet uyumlu 20 sağlıklı katılımcının 20 gözü Grup-2 retrospektif olarak çalışmaya dahil edildi. Tüm katılımcıların detaylı göz muayene bulguları kaydedildi. OKT ile elde edilen retinal kalınlıkları ve ImageJ programı yardımıyla ölçülen santral 500 ve 1000 μm genişlikteki HSLT alanı ölçülerek kaydedildi. Bulgular iki grup arasında istatistiksel olarak kıyaslandı. Bulgular: Gruplar arasında ortalama yaş ve cinsiyet dağılımı açısından anlamlı fark saptanmadı p0,05. En iyi düzeltilmiş görme keskinliği, göz içi basıncı, sferik eşdeğer, aksiyel uzunluk ve ön kamara derinliği ortalamaları iki grup arasında benzerdi tümü için p0,05. Retinal kalınlık ve koroid kalınlığı açısından da iki grup arasında istatistiksel anlamlı fark görülmedi p0,05. Ortalama HSLT alanı santral 500 μmlik bölgede Grup-1de anlamlı olarak daha yüksekti Grup-1: 25678,4  5372,0 μm2 vs. Grup-2: 23375,0  3974,5 μm2, p0,010. Santral 1000 μmlik bölgede ise iki grup arasında ortalama HSLT alanları benzerdi Grup-1: 99859,9  9936,4 μm2 vs Grup-2: 97563  8478,4 μm2, p0,090. Sonuç: Çalışmamızın bulguları, hafif dereceli ve inaktif dönemdeki TGH olan gözlerde santral foveal bölgede fotoreseptör ve Müller hücrelerinden oluşan HSLT alanında artış olduğunu göstermektedir. HSLTnin değerlendirilmesi TGHnin erken tanınması ve takibi için ümit vericidir.

Article Details

Evaluation of Henle Nerve Fiber Layer by Optical Coherence Tomography in Thyroid Eye Disease

Authors:

Mehmet Fatih Kağan Değirmenci | Nazan Acar Eser

Publisher:

Zonguldak Bulent Ecevit University

Main Topics:

Cerrahi (Diğer)

Journal:

Batı Karadeniz Tıp Dergisi Vol.8 Issue 3, pp.341-347

Document Type:

Article

Publication Date:

12/2024

Document Language:

Turkish

Document ID (Org No.):

2001337522

pISSN:

2822-4302

Henle

Müller cell

photoreceptor cell

thyroid eye diseaseFotoreseptör hücre

Henle sinir lifi tabakası

Müller hücresi

tiroid göz hastalığı

Issues

Article Details

Authors: Mehmet Fatih Kağan Değirmenci | Nazan Acar Eser

Publisher: Zonguldak Bulent Ecevit University

Main Topics: Cerrahi (Diğer)

Journal: Batı Karadeniz Tıp Dergisi Vol.8 Issue 3, pp.341-347

Document Type: Article

Publication Date: 12/2024

Document Language: Turkish

Document ID (Org No.): 2001337522

pISSN: 2822-4302

Issues

Authors:

Mehmet Fatih Kağan Değirmenci | Nazan Acar Eser

Publisher:

Zonguldak Bulent Ecevit University

Main Topics:

Cerrahi (Diğer)

Journal:

Batı Karadeniz Tıp Dergisi Vol.8 Issue 3, pp.341-347

Document Type:

Article

Publication Date:

12/2024

Document Language:

Turkish

Document ID (Org No.):

2001337522

pISSN:

2822-4302