Evaluation of Chitosan As a Potential Medical Iron (III) Ion Adsorbent

Ayer BURKE

Article Details

Evaluation of Chitosan As a Potential Medical Iron (III) Ion Adsorbent

Authors:

Ayer BURKE

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 4, pp.341-348

Document Type:

Article

Publication Date:

3/2000

Document Language:

Turkish

Document ID (Org No.):

2000757577

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Keywords:

Abstract:

 

Chitosan, a derivative of the  natural polysaccharide chitin, is known for its  biocompatibility and metal-binding capacity.  The aim of this study was to combine these  two properties of chitosan and investigate its  potential as a new iron (III) ion (ferric ion)  adsorbing agent. The development of a safe  and orally active iron chelating agent is  especially important for the treatment of  thalassemics. In this study, the  physicochemical parameters affecting the  ability of chitosan flakes to adsorb iron (III)  ions were studied by complexometric  titration. The results showed that the iron  (III) adsorption capacity of chitosan increases  with the amount of chitosan, degree of  deacetylation of chitosan, concentration of  ferric ions in solution and with the pH of the  medium. The amount of ferric ions that  adsorb on the polymer increases with time  until an equilibrium is reached between  adsorbed iron (III) ions and those in solution.  Preliminary in vitro results obtained in  human blood serum indicate that chitosan is  capable of adsorbing iron (III) ions in the  body fluid medium and may be a suitable  iron-adsorbing agent in biological systems.

 

Chitosan, a derivative of the  natural polysaccharide chitin, is known for its  biocompatibility and metal-binding capacity.  The aim of this study was to combine these  two properties of chitosan and investigate its  potential as a new iron (III) ion (ferric ion)  adsorbing agent. The development of a safe  and orally active iron chelating agent is  especially important for the treatment of  thalassemics. In this study, the  physicochemical parameters affecting the  ability of chitosan flakes to adsorb iron (III)  ions were studied by complexometric  titration. The results showed that the iron  (III) adsorption capacity of chitosan increases  with the amount of chitosan, degree of  deacetylation of chitosan, concentration of  ferric ions in solution and with the pH of the  medium. The amount of ferric ions that  adsorb on the polymer increases with time  until an equilibrium is reached between  adsorbed iron (III) ions and those in solution.  Preliminary in vitro results obtained in  human blood serum indicate that chitosan is  capable of adsorbing iron (III) ions in the  body fluid medium and may be a suitable  iron-adsorbing agent in biological systems.

Article Details

Evaluation of Chitosan As a Potential Medical Iron (III) Ion Adsorbent

Authors:

Ayer BURKE

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 4, pp.341-348

Document Type:

Article

Publication Date:

3/2000

Document Language:

Turkish

Document ID (Org No.):

2000757577

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

chitin

chitosan

iron-chelation

iron-adsorption

thalassemia.

Issues

Article Details

Evaluation of Chitosan As a Potential Medical Iron (III) Ion Adsorbent

Authors: Ayer BURKE

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2000 Vol.30 Issue 4, pp.341-348

Document Type: Article

Publication Date: 3/2000

Document Language: Turkish

Document ID (Org No.): 2000757577

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

chitin

chitosan

iron-chelation

iron-adsorption

thalassemia.

Issues

Authors:

Ayer BURKE

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 4, pp.341-348

Document Type:

Article

Publication Date:

3/2000

Document Language:

Turkish

Document ID (Org No.):

2000757577

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144