The effect of minimal-flow and high-flow hypotensive anesthesia on oxidative stress

Şule BATÇIK; Leyla KAZANCIOĞLU; Medeni ARPA; İlkay BAHÇECİ; Özcan EREL

doi:https://doi.org/10.19127/mbsjohs.936739

Article Details

The effect of minimal-flow and high-flow hypotensive anesthesia on oxidative stress

Authors:

Şule BATÇIK | Leyla KAZANCIOĞLU | Medeni ARPA | İlkay BAHÇECİ | Özcan EREL

Publisher:

Ordu University

Main Topics:

Promotion of health

Journal:

Middle Black Sea Journal of Health Science 2021 Vol.7 Issue 2, pp.221-229

Document Type:

Article

Publication Date:

8/2021

Document Language:

English

Document ID (Org No.):

2000563942

Frequency:

Tri-annual

eISSN:

2149-7796

DOI:

https://doi.org/10.19127/mbsjohs.936739

Abstract:

 


Objective: The main objective of this study was to compare the effects of minimal and high gas flow-controlled hypotension applications on IMA and thiol/disulfide balance, which are indicators of oxidative stress.

Methods: Patients undergoing elective tympanoplasty were randomized to two groups as minimal-flow and high-flow anesthesia groups. Minimal flow anesthesia was performed with 5L/min fresh gas flow reduced to 0.4 L/min. High flow was administered as 2 L/min fresh gas. Preoperative and intraoperative SpO2, StO2, EtCO2, mean arterial pressure and heart rate values were recorded. Preoperative and intraoperative IMA, total thiol, native thiol, disulfide, disulfide/native thiol and disulfide/total thiol values were recorded and compared between the two groups.   

Results: The mean intraoperative arterial pressure was statistically notably higher in the high flow group (p=0.048). The mean intraoperative SPO2 value was remarkably higher in the minimal flow group (p=0.032). The mean EtCO2 value was notably lower in the minimal flow group at 5 minutes and 15 minutes of the operation (p=0.029; p=0.048). The mean preoperative and intraoperative IMA values were statistically notably higher in the minimal flow group compared to the high flow group (for both, p=0.001). There was no remarkable difference between the groups in terms of the other monitored parameters (for all, p>0.05).

Conclusion: IMA value was found to be significantly higher with minimal-flow anesthesia. However, no notable difference was found in terms of thiol/disulfide homeostasis, indicating the need for further comprehensive studies in order to draw a definitive conclusion

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Article Details

The effect of minimal-flow and high-flow hypotensive anesthesia on oxidative stress

Authors: Şule BATÇIK | Leyla KAZANCIOĞLU | Medeni ARPA | İlkay BAHÇECİ | Özcan EREL

Publisher: Ordu University

Main Topics: Promotion of health

Journal: Middle Black Sea Journal of Health Science 2021 Vol.7 Issue 2, pp.221-229

Document Type: Article

Publication Date: 8/2021

Document Language: English

Document ID (Org No.): 2000563942

Frequency: Tri-annual

eISSN: 2149-7796

DOI: https://doi.org/10.19127/mbsjohs.936739

Issues

Authors:

Şule BATÇIK | Leyla KAZANCIOĞLU | Medeni ARPA | İlkay BAHÇECİ | Özcan EREL

Publisher:

Ordu University

Main Topics:

Promotion of health

Journal:

Middle Black Sea Journal of Health Science 2021 Vol.7 Issue 2, pp.221-229

Document Type:

Article

Publication Date:

8/2021

Document Language:

English

Document ID (Org No.):

2000563942

Frequency:

Tri-annual

eISSN:

2149-7796

DOI:

https://doi.org/10.19127/mbsjohs.936739