Central nervous system depressant, gastrointestinal motility, and brine shrimp lethality bioassay of the methanolic extract of Suaeda maritima in mice model

N.A.

Article Details

Central nervous system depressant, gastrointestinal motility, and brine shrimp lethality bioassay of the methanolic extract of Suaeda maritima in mice model

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacognosy | Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.26 Issue 6, pp.1868-1876

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347796

pISSN:

2630-6344

Keywords:

Abstract:

 Suaeda maritima S. maritima is a common yellow-green shrub grows in salt marshes. Present study aims to investigate the in-vivo central nervous system depressant, gastrointestinal motility and Brine shrimp lethality bioassay of the methanolic extract of S. maritima. Phytochemical screening was performed to observe the main constituents. Central nervous system depressant activity was evaluated through open field and hole cross tests separately. Gastrointestinal motility activity was observed using charcoal meal method. The extract was screened for cytotoxic activity using brine shrimp lethality bioassay. In open field method, the number of squares crossed by mice were 80.80  1.66 and 80.60  1.66 for 250 mgkg and 500 mgkg extract respectively at zero time, which reduced gradually to 26.00  1.05 and 20.00  0.95 after 60 minutes. Similar decreasing was found in hole cross method. Locomotor activities and exploratory behavior of mice were found to be decreased after the oral administration of S. maritima. On the other hand, S. maritima extract inhibit 62.9 and 69.7 gastrointestinal motility for 200 mgkg and 400 mgkg body weight of dose. In brine shrimp lethality test, LC50 values obtained from the experiment were 0.451 µgµl and 0.254 µgµl for S. maritima extract and positive control vincristine sulphate respectively. This study confirms the moderate cytotoxic effect of S. maritima that implies the presence of potent bioactive compounds. S. maritima possessed remarkable central nervous system depressant and gastrointestinal motility activities with moderate cytotoxic activity. Further investigation is warranted to find out the bioactive components with their exact mechanism of actions for drug development program.

 Suaeda maritima S. maritima is a common yellow-green shrub grows in salt marshes. Present study aims to investigate the in-vivo central nervous system depressant, gastrointestinal motility and Brine shrimp lethality bioassay of the methanolic extract of S. maritima. Phytochemical screening was performed to observe the main constituents. Central nervous system depressant activity was evaluated through open field and hole cross tests separately. Gastrointestinal motility activity was observed using charcoal meal method. The extract was screened for cytotoxic activity using brine shrimp lethality bioassay. In open field method, the number of squares crossed by mice were 80.80  1.66 and 80.60  1.66 for 250 mgkg and 500 mgkg extract respectively at zero time, which reduced gradually to 26.00  1.05 and 20.00  0.95 after 60 minutes. Similar decreasing was found in hole cross method. Locomotor activities and exploratory behavior of mice were found to be decreased after the oral administration of S. maritima. On the other hand, S. maritima extract inhibit 62.9 and 69.7 gastrointestinal motility for 200 mgkg and 400 mgkg body weight of dose. In brine shrimp lethality test, LC50 values obtained from the experiment were 0.451 µgµl and 0.254 µgµl for S. maritima extract and positive control vincristine sulphate respectively. This study confirms the moderate cytotoxic effect of S. maritima that implies the presence of potent bioactive compounds. S. maritima possessed remarkable central nervous system depressant and gastrointestinal motility activities with moderate cytotoxic activity. Further investigation is warranted to find out the bioactive components with their exact mechanism of actions for drug development program.

 Suaeda maritima S. maritima is a common yellow-green shrub grows in salt marshes. Present study aims to investigate the in-vivo central nervous system depressant, gastrointestinal motility and Brine shrimp lethality bioassay of the methanolic extract of S. maritima. Phytochemical screening was performed to observe the main constituents. Central nervous system depressant activity was evaluated through open field and hole cross tests separately. Gastrointestinal motility activity was observed using charcoal meal method. The extract was screened for cytotoxic activity using brine shrimp lethality bioassay. In open field method, the number of squares crossed by mice were 80.80  1.66 and 80.60  1.66 for 250 mgkg and 500 mgkg extract respectively at zero time, which reduced gradually to 26.00  1.05 and 20.00  0.95 after 60 minutes. Similar decreasing was found in hole cross method. Locomotor activities and exploratory behavior of mice were found to be decreased after the oral administration of S. maritima. On the other hand, S. maritima extract inhibit 62.9 and 69.7 gastrointestinal motility for 200 mgkg and 400 mgkg body weight of dose. In brine shrimp lethality test, LC50 values obtained from the experiment were 0.451 µgµl and 0.254 µgµl for S. maritima extract and positive control vincristine sulphate respectively. This study confirms the moderate cytotoxic effect of S. maritima that implies the presence of potent bioactive compounds. S. maritima possessed remarkable central nervous system depressant and gastrointestinal motility activities with moderate cytotoxic activity. Further investigation is warranted to find out the bioactive components with their exact mechanism of actions for drug development program.

 Suaeda maritima S. maritima is a common yellow-green shrub grows in salt marshes. Present study aims to investigate the in-vivo central nervous system depressant, gastrointestinal motility and Brine shrimp lethality bioassay of the methanolic extract of S. maritima. Phytochemical screening was performed to observe the main constituents. Central nervous system depressant activity was evaluated through open field and hole cross tests separately. Gastrointestinal motility activity was observed using charcoal meal method. The extract was screened for cytotoxic activity using brine shrimp lethality bioassay. In open field method, the number of squares crossed by mice were 80.80  1.66 and 80.60  1.66 for 250 mgkg and 500 mgkg extract respectively at zero time, which reduced gradually to 26.00  1.05 and 20.00  0.95 after 60 minutes. Similar decreasing was found in hole cross method. Locomotor activities and exploratory behavior of mice were found to be decreased after the oral administration of S. maritima. On the other hand, S. maritima extract inhibit 62.9 and 69.7 gastrointestinal motility for 200 mgkg and 400 mgkg body weight of dose. In brine shrimp lethality test, LC50 values obtained from the experiment were 0.451 µgµl and 0.254 µgµl for S. maritima extract and positive control vincristine sulphate respectively. This study confirms the moderate cytotoxic effect of S. maritima that implies the presence of potent bioactive compounds. S. maritima possessed remarkable central nervous system depressant and gastrointestinal motility activities with moderate cytotoxic activity. Further investigation is warranted to find out the bioactive components with their exact mechanism of actions for drug development program.

Article Details

Central nervous system depressant, gastrointestinal motility, and brine shrimp lethality bioassay of the methanolic extract of Suaeda maritima in mice model

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacognosy | Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.26 Issue 6, pp.1868-1876

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347796

pISSN:

2630-6344

Suaeda maritima

central nervous system depressant

hole cross

gastrointestinal motility

open field

brineshrimp

Issues

Article Details

Central nervous system depressant, gastrointestinal motility, and brine shrimp lethality bioassay of the methanolic extract of Suaeda maritima in mice model

Authors: N.A.

Publisher: Marmara University

Main Topics: Pharmacognosy | Pharmacology and Pharmaceutical Sciences (Other)

Journal: Journal of Research in Pharmacy Vol.26 Issue 6, pp.1868-1876

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001347796

pISSN: 2630-6344

Suaeda maritima

central nervous system depressant

hole cross

gastrointestinal motility

open field

brineshrimp

Issues

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacognosy | Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.26 Issue 6, pp.1868-1876

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347796

pISSN:

2630-6344