Immunohistochemical Expression of Endocan in Ameloblastoma

Salam N. Jawad; Bashar H. Abdullah

doi:10.12816/0033213

Article Details

Immunohistochemical Expression of Endocan in Ameloblastoma

Authors:

Salam N. Jawad | Bashar H. Abdullah

Publisher:

College of Dentistry : University of Baghdad

Main Topics:

Medicine

Journal:

Journal of Baghdad College of Dentistry 2016 Vol.28 Issue 4, pp.68-71

Document Type:

Article

Publication Date:

12/2016

Document Language:

English

Document ID (Org No.):

96447

Frequency:

Quarterly

eISSN:

23115270

pISSN:

16800087

DOI:

10.12816/0033213

Descriptors:

Keywords:

Abstract:

 Background: Ameloblastoma is the most common clinically significant odontogenic tumor, known for its locally invasive potential and frequent recurrences unless treated radically. Endocan is a soluble proteoglycan which is reported to have prognostic implications in multiple human diseases and tumors. This study aims to describe the expression of endocan in ameloblastoma. Materials and methods: With immunoperoxidase method; tissue sections of formalin fixed- paraffin embedded blocks for ameloblastomas were stained with monoclonal antibodies to endocan, the localization of the endocan expression was examined and the resulting scores of the tissue sections were analyzed according to age, sex, site and tumor subtype. Results: endocan was found to be expressed in peripheral and central epithelial cells of ameloblastoma tumor islands and stroma to different extents; a selectively increased expression was noted in epithelial cells with acanthomatous differentiation. Tumor epithelial cells of plexiform subtype tend to have higher expression levels of endocan. However, the associations did not reach statistically significant levels. Conclusions: Endocan is expressed specifically in various populations of tumor epithelial cells and stromal elements of ameloblastoma. The prognostic significance of the expression needs to be clarified in further studies.

Article Details

Immunohistochemical Expression of Endocan in Ameloblastoma

Authors:

Salam N. Jawad | Bashar H. Abdullah

Publisher:

College of Dentistry : University of Baghdad

Main Topics:

Medicine

Journal:

Journal of Baghdad College of Dentistry 2016 Vol.28 Issue 4, pp.68-71

Document Type:

Article

Publication Date:

12/2016

Document Language:

English

Document ID (Org No.):

96447

Frequency:

Quarterly

eISSN:

23115270

pISSN:

16800087

DOI:

10.12816/0033213

Descriptors:

IMMUNOHISTOCHEMISTRY

IMMUNOLOGICAL TECHNIQUES

ENDOTHELIAL CELLS

EPITHELIAL CELLS

CELL PATHOLOGY

MOUTH DISEASES

DENTISTRY

Ameloblastoma

Endocan

Issues

Article Details

Authors: Salam N. Jawad | Bashar H. Abdullah

Publisher: College of Dentistry : University of Baghdad

Main Topics: Medicine

Journal: Journal of Baghdad College of Dentistry 2016 Vol.28 Issue 4, pp.68-71

Document Type: Article

Publication Date: 12/2016

Document Language: English

Document ID (Org No.): 96447

Frequency: Quarterly

eISSN: 23115270

pISSN: 16800087

DOI: 10.12816/0033213

Descriptors:

Issues

Authors:

Salam N. Jawad | Bashar H. Abdullah

Publisher:

College of Dentistry : University of Baghdad

Main Topics:

Medicine

Journal:

Journal of Baghdad College of Dentistry 2016 Vol.28 Issue 4, pp.68-71

Document Type:

Article

Publication Date:

12/2016

Document Language:

English

Document ID (Org No.):

96447

Frequency:

Quarterly

eISSN:

23115270

pISSN:

16800087

DOI:

10.12816/0033213