The effects of CAPE on oxidative stress and histopathological values in rats treated with subacute dichlorvos

Gökhan NUR; Aysel GÜVEN; Pınar AKSU KILIÇLE

doi:https://doi.org/10.37212/jcnos.418660

Article Details

The effects of CAPE on oxidative stress and histopathological values in rats treated with subacute dichlorvos

Authors:

Gökhan NUR | Aysel GÜVEN | Pınar AKSU KILIÇLE

Publisher:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Journal:

Journal of Cellular Neuroscience and Oxidative Stress 2018 Vol.10 Issue 1, pp.647-655

Document Type:

Article

Publication Date:

4/2018

Document Language:

English

Document ID (Org No.):

2000708900

Frequency:

Tri-annual

eISSN:

2149-7222

DOI:

https://doi.org/10.37212/jcnos.418660

Abstract:

 


This study was designed to investigate the protective effect of CAPE against dichlorvos induced hepatotoxicity in rats. 40 rats were used in the study, including 10 in each group. Corn oil of 5 mg/kg (solvent) was administered intragastrically to rats in the group 1, dichlorvos of 5 mg/kg was dissolved in corn oil and administered to rats in the group 2 via gavage, dichlorvos (5 mg/kg, via gavage route) and CAPE (10 μM/kg, intraperitoneally) were administered to rats of the group 3 with one-hour interval providing that CAPE treatment was started three days earlier than dichlorvos administration. The rats in the group 4 were administered with 10% solvent ethanol via intraperitoneally. All administrations continued for 15 days and blood of animals was drawn via intracardiac route after they were sacrificed by cervical dislocation under ketamine/xylazine anesthesia. Total antioxidant, total oxidant, and paraoxonase levels were measured from the obtained plasma samples. As a result of dichlorvos administration, paraoxonase activity and total antioxidant levels decreased; whereas, total oxidant levels increased. Histopathological analysis revealed that liver tissue appeared normal in control groups (1 and 4); on the other hand, there were degeneration, congestion, cellular infiltration, and necrotic areas in the group administered with dichlorvos. Even though frequency of lesions decreased, similar lesions were observed in the group with Dichlorvos+CAPE. Consequently, it was determined that while dichlorvos administration increased oxidative stress, CAPE administration had a protective potential increasing antioxidant capacity.

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Article Details

The effects of CAPE on oxidative stress and histopathological values in rats treated with subacute dichlorvos

Authors: Gökhan NUR | Aysel GÜVEN | Pınar AKSU KILIÇLE

Publisher: Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Journal: Journal of Cellular Neuroscience and Oxidative Stress 2018 Vol.10 Issue 1, pp.647-655

Document Type: Article

Publication Date: 4/2018

Document Language: English

Document ID (Org No.): 2000708900

Frequency: Tri-annual

eISSN: 2149-7222

DOI: https://doi.org/10.37212/jcnos.418660

Issues

Authors:

Gökhan NUR | Aysel GÜVEN | Pınar AKSU KILIÇLE

Publisher:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Journal:

Journal of Cellular Neuroscience and Oxidative Stress 2018 Vol.10 Issue 1, pp.647-655

Document Type:

Article

Publication Date:

4/2018

Document Language:

English

Document ID (Org No.):

2000708900

Frequency:

Tri-annual

eISSN:

2149-7222

DOI:

https://doi.org/10.37212/jcnos.418660