Effect of Honey Supplementation on Clostridium Difficile Infection in Childhood Cancer

Mohsen Saleh El Alfy; Iman Ahmed Ragab; Sally Mohamed Saber; Yasmin Gamal El Gendy; Zahia Shahat El Sayed

doi:10.12816/0045662

Article Details

Effect of Honey Supplementation on Clostridium Difficile Infection in Childhood Cancer

Authors:

Mohsen Saleh El Alfy | Iman Ahmed Ragab | Sally Mohamed Saber | Yasmin Gamal El Gendy | Zahia Shahat El Sayed

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2018 Vol.71 Issue 2, pp.2593-2602

Document Type:

Article

Publication Date:

4/2018

Document Language:

English

Document ID (Org No.):

115592

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0045662

Descriptors:

Keywords:

Abstract:

 Background: the treatment of cancer is associated with nausea and vomiting, oral mucositis, constipation, xerostomia and diarrhea and weight loss, additionally; chemotherapeutic agents promote inflammatory changes in the gut, intestinal necrosis, and anaerobic conditions, allowing proliferation of Clostridium Difficile. Honey, as a natural honeybee product, has antioxidant, antimicrobial, immunomodulatory and anticancer effects. Honey can fight microbial infection by its immuno-activating, anti-inflammatory and prebiotic activity.Objectives: the aim of this study was to evaluate the effect of honey supplementation on frequency of Clostridium Difficile infection (CDI) and gastrointestinal complications in pediatric patients undergoing chemotherapy.Design: a cross sectional study conducted on 40 patients with malignancy recruited from Children's Hospital, Ain Shams University, Oncology Unit and Clinic, Cairo, Egypt in the period from December 2015 to December 2016. Patients were divided into two groups; group I (25 patients) received honey in the dose of 2gm/kg 3 times dailyfor 1month) while group II (15 patients) did not receive honey. All the studied patients were subjected to medical history and clinical examination, with special emphasis on gastrointestinal complication including oral mucositis, vomiting, diarrhea, constipation, and abdominal pain. Follow up was done for weight, height z score, gastrointestinal complications and any adverse events. Stool analysis, culture, C difficle toxin A, B by ELISA was done to all patients at baseline and repeated to patients receiving honey at week 4 of supplementation. Main outcome measure frequency of CDI, gastrointestinal complication, febrile neutropenia .Results: the frequency of C difficle was 8% (2), the first case was 9 years old patient with ALL (50%) and the other 11 years old patient with Burkitts lymphoma both were diagnosed by positive stool culture and positive stool ELISA for toxin A, B. gastrointestinal complications were significantly less and improved in the supplemented group and mean of hemoglobin significant increase in group 1.Conclusion: the frequency of CDI in children with cancer 8% diagnosed by stool culture and toxin A, B study in stool. Honey improved the oral mucositis and different GIT complications associated with chemotherapy

Article Details

Effect of Honey Supplementation on Clostridium Difficile Infection in Childhood Cancer

Authors:

Mohsen Saleh El Alfy | Iman Ahmed Ragab | Sally Mohamed Saber | Yasmin Gamal El Gendy | Zahia Shahat El Sayed

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2018 Vol.71 Issue 2, pp.2593-2602

Document Type:

Article

Publication Date:

4/2018

Document Language:

English

Document ID (Org No.):

115592

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0045662

Descriptors:

FEED SUPPLEMENTS

HONEY

CLOSTRIDIUM

INFECTION

CANCER

CHEMOTHERAPY

CHILDHOOD

PAEDIATRICS

Honey

Clostridium Difficle

Childhood Cancer

Chemotherapy

Issues

Article Details

Authors: Mohsen Saleh El Alfy | Iman Ahmed Ragab | Sally Mohamed Saber | Yasmin Gamal El Gendy | Zahia Shahat El Sayed

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2018 Vol.71 Issue 2, pp.2593-2602

Document Type: Article

Publication Date: 4/2018

Document Language: English

Document ID (Org No.): 115592

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

DOI: 10.12816/0045662

Descriptors:

Issues

Authors:

Mohsen Saleh El Alfy | Iman Ahmed Ragab | Sally Mohamed Saber | Yasmin Gamal El Gendy | Zahia Shahat El Sayed

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2018 Vol.71 Issue 2, pp.2593-2602

Document Type:

Article

Publication Date:

4/2018

Document Language:

English

Document ID (Org No.):

115592

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0045662