Granulocyte-Colony Stimulating Factor Prevents Motor Dysfunction and Histological Damages in a Rat Model of Parkinson's Disease

Mariama S. Azmy; Esther T. Menze; Reem N. El-Naga; Mariane G. Tadros

doi:10.12816/0040111

Article Details

Granulocyte-Colony Stimulating Factor Prevents Motor Dysfunction and Histological Damages in a Rat Model of Parkinson's Disease

Authors:

Mariama S. Azmy | Esther T. Menze | Reem N. El-Naga | Mariane G. Tadros

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2017 Vol.69 Issue 1, pp.1628-1633

Document Type:

Article

Publication Date:

10/2017

Document Language:

English

Document ID (Org No.):

107755

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0040111

Descriptors:

Keywords:

Abstract:

 Aim of the work: Parkinson’s disease is the most common neurodegenerative movement disorder worldwide.
The main motor clinical manifestations of Parkinson’s disease are resting tremors, bradykinesia, rigidity, and
postural instability. In the present study, we aimed to evaluate the effects of granulocyte-colony stimulating
factor (G-CSF) on the body weight, motor function, and brain histology of rotenone-treated rats.
Material and methods: Rats were divided into four groups, as follows: Group 1 the control rats, Group 2 the
rotenone-treated rats (2 mg/kg, 28 days), Group 3 the rotenone + G-CSF (20 μg/kg, 28 days)-treated rats and
Group 4 the rotenone + G-CSF (40 μg/kg, 28 days)-treated rats. Body weight was measured on weekly basis.
Postural instability was evaluated at the end of the study and the motor behavior was monitored. Then, rats were
decapitated and brain histology was examined. Results: Rotenone resulted in body weight loss,
bradykinesia/akinesia, rigidity, postural instability, and histological damages. All these deficits were prevented
by G-CSF at 40 μg/kg. Therefore, G-CSF may be a potential neuroprotective agent in Parkinson’s disease.

Article Details

Granulocyte-Colony Stimulating Factor Prevents Motor Dysfunction and Histological Damages in a Rat Model of Parkinson's Disease

Authors:

Mariama S. Azmy | Esther T. Menze | Reem N. El-Naga | Mariane G. Tadros

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2017 Vol.69 Issue 1, pp.1628-1633

Document Type:

Article

Publication Date:

10/2017

Document Language:

English

Document ID (Org No.):

107755

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0040111

Descriptors:

GRANULOCYTES

DYSFUNCTION

BRAIN DISEASES

ROTENONE

WEIGHT

PHARMACOLOGY

RATS

LABORATORY ANIMALS

G-CSF

Rotenone

Body Weight

Postural Instability

Issues

Article Details

Authors: Mariama S. Azmy | Esther T. Menze | Reem N. El-Naga | Mariane G. Tadros

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2017 Vol.69 Issue 1, pp.1628-1633

Document Type: Article

Publication Date: 10/2017

Document Language: English

Document ID (Org No.): 107755

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

DOI: 10.12816/0040111

Descriptors:

Issues

Authors:

Mariama S. Azmy | Esther T. Menze | Reem N. El-Naga | Mariane G. Tadros

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2017 Vol.69 Issue 1, pp.1628-1633

Document Type:

Article

Publication Date:

10/2017

Document Language:

English

Document ID (Org No.):

107755

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0040111