The effect of topical 5-Fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve

Melekber CAVUS OZKAN; Betul TUNCEL; Guzin Yesim OZGENEL

doi:https://doi.org/10.5472/marumj.342046

Article Details

The effect of topical 5-Fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve

Authors:

Melekber CAVUS OZKAN | Betul TUNCEL | Guzin Yesim OZGENEL

Publisher:

Marmara University

Main Topics:

Diseases

Journal:

Marmara Medical Journal 2018 Vol.31 Issue 1, pp.1-10

Document Type:

Article

Publication Date:

1/2018

Document Language:

English

Document ID (Org No.):

2000544449

Frequency:

Monthly

eISSN:

1309-9469

pISSN:

1019-1941

DOI:

https://doi.org/10.5472/marumj.342046

Abstract:

 


Objective: This study investigated the
effect of topical 5-Fluorouracil (5-FU) application on the epineural scar
tissue, which has a negative impact on the outcome after a peripheral nerve
surgery, and whether the application of two doses of 5-FU would change the
outcome.


     Materials and Methods: The study involved 72
3-month-old female Spradue-Dawey rats weighing 250-300 g each. After the
experimental animals were observed for a week to make certain that they were
healthy, they were randomly divided into 3 main groups; Group A: skin incision
+ epineurotomy + isotonic (n=24), Group B: skin incision + epineurotomy +
single dose of 5-FU (n=24) and Group C: skin incision + epineurotomy + two
doses of 5-FU (n=24). Each group was divided into 2 subgroups based on the
weeks in which they were examined. The two subgroups in each of the three
groups were made subject to a walking test, and macroscopic and histopathological
examinations at Week 4 and Week 8. 


     Results: An evaluation of the
macroscopic results showed that there was a statistically significant difference
between Group A and Group C in sciatic nerve adhesion and severability of its
branches. We obtained better results in Group C,  when compared 
with the results obtained in Group A.       







     Conclusion:
We demonstrated in our
study that 5-FU had a positive effect on the scar tissue developed around the
epineurectomized nerve. This positive effect was also reflected in the nerve’s
functional capacity, and a second dose of 5-FU application further improved
this effect.

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Article Details

The effect of topical 5-Fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve

Authors: Melekber CAVUS OZKAN | Betul TUNCEL | Guzin Yesim OZGENEL

Publisher: Marmara University

Main Topics: Diseases

Journal: Marmara Medical Journal 2018 Vol.31 Issue 1, pp.1-10

Document Type: Article

Publication Date: 1/2018

Document Language: English

Document ID (Org No.): 2000544449

Frequency: Monthly

eISSN: 1309-9469

pISSN: 1019-1941

DOI: https://doi.org/10.5472/marumj.342046

Issues

Authors:

Melekber CAVUS OZKAN | Betul TUNCEL | Guzin Yesim OZGENEL

Publisher:

Marmara University

Main Topics:

Diseases

Journal:

Marmara Medical Journal 2018 Vol.31 Issue 1, pp.1-10

Document Type:

Article

Publication Date:

1/2018

Document Language:

English

Document ID (Org No.):

2000544449

Frequency:

Monthly

eISSN:

1309-9469

pISSN:

1019-1941

DOI:

https://doi.org/10.5472/marumj.342046