Immunohistocshemical Expression of CD44 and MMP-9 in Oral Squamous Cell Carcinoma

Mohamed Salah El-Din Ayoub; Mohamed Hossam Eldin Elmalahy; Ashraf S. Abokhalaf; Melad Abdullah Al-Swehly

doi:10.12816/0032629

Article Details

Immunohistocshemical Expression of CD44 and MMP-9 in Oral Squamous Cell Carcinoma

Authors:

Mohamed Salah El-Din Ayoub | Mohamed Hossam Eldin Elmalahy | Ashraf S. Abokhalaf | Melad Abdullah Al-Swehly

Publisher:

Ain Shams University : Faculty of Dentistry

Main Topics:

Medicine

Journal:

Ain Shams Dental Journal 2015 Vol.18 Issue 1, pp.33-38

Document Type:

Article

Publication Date:

3/2015

Document Language:

English

Document ID (Org No.):

95819

Frequency:

Quarterly

pISSN:

11107642

DOI:

10.12816/0032629

Descriptors:

Keywords:

Abstract:

 Squamous cell carcinomas (SCCs) account for approximately 95%of all oral malignantneoplasms and for about 38%of all malignant head and neck tumors, especially affecting thetongue and lips. The aim of this study was to evaluate the immunohistochemical expressionof CD44 AND MMP-9 in oral SCC according to the occurrence of metastasis.In spite of the progresses achieved in surgical treatment, radiotherapy and chemotherapy,the survival rate in oral squamous cell carcinoma (OSCC) remain unchanged among past threedecades, which made this neoplasia a major problem of health in the entire world. Therewere investigated 45 cases of OSCC with different sites and various grades of differentiation,by histological and immunohistochemical techniques, using CD44and MMP9. Consideringthe differentiation grade, the cases were histopathologically classified as 15 cases of welldifferentiatedsquamous carcinoma, 15 cases of moderately differentiatedsquamous carcinoma,and 15 cases of poorly differentiated squamous carcinoma. The results of CD44 and MMP9immunostaining indicated in most of the cases positive immunostaining .

Article Details

Immunohistocshemical Expression of CD44 and MMP-9 in Oral Squamous Cell Carcinoma

Authors:

Mohamed Salah El-Din Ayoub | Mohamed Hossam Eldin Elmalahy | Ashraf S. Abokhalaf | Melad Abdullah Al-Swehly

Publisher:

Ain Shams University : Faculty of Dentistry

Main Topics:

Medicine

Journal:

Ain Shams Dental Journal 2015 Vol.18 Issue 1, pp.33-38

Document Type:

Article

Publication Date:

3/2015

Document Language:

English

Document ID (Org No.):

95819

Frequency:

Quarterly

pISSN:

11107642

DOI:

10.12816/0032629

Descriptors:

MOUTH DISEASES

SQUAMOUS CARCINOMA

CANCER

ORAL HEALTH

PATIENTS

Oral Squamous Cell Carcinoma

CD44

MMP9

Issues

Article Details

Authors: Mohamed Salah El-Din Ayoub | Mohamed Hossam Eldin Elmalahy | Ashraf S. Abokhalaf | Melad Abdullah Al-Swehly

Publisher: Ain Shams University : Faculty of Dentistry

Main Topics: Medicine

Journal: Ain Shams Dental Journal 2015 Vol.18 Issue 1, pp.33-38

Document Type: Article

Publication Date: 3/2015

Document Language: English

Document ID (Org No.): 95819

Frequency: Quarterly

pISSN: 11107642

DOI: 10.12816/0032629

Descriptors:

Issues

Authors:

Mohamed Salah El-Din Ayoub | Mohamed Hossam Eldin Elmalahy | Ashraf S. Abokhalaf | Melad Abdullah Al-Swehly

Publisher:

Ain Shams University : Faculty of Dentistry

Main Topics:

Medicine

Journal:

Ain Shams Dental Journal 2015 Vol.18 Issue 1, pp.33-38

Document Type:

Article

Publication Date:

3/2015

Document Language:

English

Document ID (Org No.):

95819

Frequency:

Quarterly

pISSN:

11107642

DOI:

10.12816/0032629