The relationship between Helicobacter pylori and DNA hypermethylation in gastric cancer

Ayşe Feyda Nursal

Article Details

The relationship between Helicobacter pylori and DNA hypermethylation in gastric cancer

Authors:

Ayşe Feyda Nursal

Publisher:

Eldaghayes Publisher

Journal:

Journal of Microbiology and Infectious Diseases Vol.5 Issue 4, pp.187-187

Document Type:

Article

Publication Date:

1/1970

Document Language:

English

Document ID (Org No.):

2001529553

pISSN:

2146-9369

Abstract:

 Gastric cancer (GC) is one of the most common types of cancer across the world. GC carcinogenesis demonstrates a multi-step progression with the accumulation of genetic and epigenetic changes. The genetic changes on gene expres¬sion, without any change on deoxyribonucleic acid (DNA) sequencing, are named as ”epigenetic”. DNA methylation is the most commonly studied epigenetic modification in mammalians. Hypermethylation is observed on CpG (—C—phosphate—G—) islands in promoter regions of genes. This is a significant mechanism that causes functional losses in tumor suppressor genes. In gastric cancer, DNA hypermethylation is seen in many genes. Helicobacter pylori (H. pylori) are a type of spiral-shaped Gram-negative bacteria. It infects approximately half of the world \'s population. H. pylori is an important etiological factor that causes GC in human beings. Chronic H. pylori infection in human is associated with hypermethylation of promoter sequences of different genes. This paper provides a review of the current literature on the relationship between H. pylori infection and DNA hypermethylation in GC. J Microbiol Infect Dis 2015;5(4): 187-190Ayşe Feyda Nursal, Giresun Üniversitesi Tıp Fakültesi Tıbbi Genetik AD, Giresun, Türkiye, The relationship between Helicobacter pylori and DNA hypermethylation in gastric cancer,Ayşe Feyda Nursal, Giresun Üniversitesi Tıp Fakültesi Tıbbi Genetik AD, Giresun, Türkiye J Microbiol Infect Dis 2015;5(4): 187-190 doi: 10.5799/ahinjs.02.2015.04.0204.

Article Details

The relationship between Helicobacter pylori and DNA hypermethylation in gastric cancer

Authors: Ayşe Feyda Nursal

Publisher: Eldaghayes Publisher

Journal: Journal of Microbiology and Infectious Diseases Vol.5 Issue 4, pp.187-187

Document Type: Article

Publication Date: 1/1970

Document Language: English

Document ID (Org No.): 2001529553

pISSN: 2146-9369

Issues

Authors:

Ayşe Feyda Nursal

Publisher:

Eldaghayes Publisher

Journal:

Journal of Microbiology and Infectious Diseases Vol.5 Issue 4, pp.187-187

Document Type:

Article

Publication Date:

1/1970

Document Language:

English

Document ID (Org No.):

2001529553

pISSN:

2146-9369